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Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder

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Author(s)
Yun-Mee LhoEunyoung HaChul-Hyun ChoKwang-Soon SongByung-Woo MinKi-Cheor BaeKyung-Jae LeeIlseon HwangHyung-Bin Park
Keimyung Author(s)
Cho, Chul HyunSong, Kwang SoonMin, Byung WooBae, Ki CheorLee, Kyung JaeHa, Eun YoungHwang, Il Seon
Department
Dept. of Biochemistry (생화학)
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Pathology (병리학)
Journal Title
Journal of Shoulder and Elbow Surgery
Issued Date
2013
Volume
22
Issue
5
Keyword
Frozen shoulderjoint capsulesubacromial bursacytokinesinflammationfibrosis
Abstract
Background:
Frozen shoulder is a debilitating condition characterized by gradual loss of glenohumeral motion with chronic inflammation and capsular fibrosis. Yet its pathogenesis remains largely unknown. We hypothesized that the subacromial bursa may be responsible for the pathogenesis of frozen shoulder by producing inflammatory cytokines.


Materials and methods:

We obtained joint capsules and subacromial bursae from 14 patients with idiopathic frozen shoulder and from 7 control subjects to determine the expression levels of interleukin (IL) 1α, IL-1β, IL-6, tumor necrosis factor α (TNF-α), cyclooxygenase (COX) 1, and COX-2 by real-time reverse transcriptase–polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.


Results:

IL-1α, IL-1β, TNF-α, COX-1, and COX-2 were expressed at significantly high levels in the joint capsules of the frozen shoulder group compared with those of the control group. Intriguingly, IL-1α, TNF-α, and COX-2 were also expressed at significantly high levels in the subacromial bursae of the frozen shoulder group compared with those of the control group. Immunohistochemical analysis showed increased expression of COX-2 in both the joint capsules and subacromial bursae of the frozen shoulder group.


Conclusions:

These findings imply that elevated levels of inflammatory cytokines in the subacromial bursa may be associated with the pathogenesis of inflammation evolving into fibrosis.
Keimyung Author(s)(Kor)
조철현
송광순
민병우
배기철
이경재
하은영
황일선
Publisher
School of Medicine
Citation
Yun-Mee Lho et al. (2013). Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder. Journal of Shoulder and Elbow Surgery, 22(5), 666–672. doi: 10.1016/j.jse.2012.06.014
Type
Article
ISSN
1058-2746
Source
https://www.sciencedirect.com/science/article/pii/S1058274612002777?via%3Dihub
DOI
10.1016/j.jse.2012.06.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33885
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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