IS6110-Restriction Fragment Length Polymorphism and Spoligotyping Analysis of Mycobacterium tuberculosis Clinical Isolates for Investigating Epidemiologic Distribution in Korea
- Affiliated Author(s)
- 류남희
- Alternative Author(s)
- Ryoo, Nam Hee
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2010
- Keyword
- Mycobacterium tuberculosis; IS6110-RFLP; Spoligotyping; Beijing Family; K Strain
- Abstract
- The Beijing family of Mycobacterium tuberculosis has been emerging in the world.
However, there are few nationwide data of genotypic distribution in Korea. This study
aimed to identify the genotypic diversity of clinical isolates of M. tuberculosis and to
demonstrate the population of Beijing family in Korea. We collected 96 clinical M.
tuberculosis isolates from 11 university hospitals nationwide in Korea from 2008 to
2009. We observed 24 clusters in IS6110-RFLP analysis and 19 patterns in
spoligotyping. Seventy-five isolates were confirmed to be Beijing family. Two isolates
of the K strain and 12 isolates of the K family strain were also found. We found that
drug resistance phenotypes were more strongly associated with Beijing family than
non-Beijing family (P=0.003). This study gives an overview of the distribution of
genotypes of M. tuberculosis in Korea. These findings indicate that we have to pay
more attention to control of M. tuberculosis strains associated with the Beijing family.
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