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IS6110-Restriction Fragment Length Polymorphism and Spoligotyping Analysis of Mycobacterium tuberculosis Clinical Isolates for Investigating Epidemiologic Distribution in Korea

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Author(s)
Go Eun ChoiMi Hee JangEun Ju SongSeok Hoon JeongJae-Seok KimWee Gyo LeeYoung UhKyoung Ho RohHye Soo LeeJong Hee ShinNam Hee RyooYoung Ree KimJoseph JeongJee Hee KimSun Min LeeJongyoun YiSang Hyun HwangHyung Hoi KimEun Yup LeeChulhun L. ChangMoon-Bum KimYeong Dae Kim
Keimyung Author(s)
Ryoo, Nam Hee
Department
Dept. of Laboratory Medicine (진단검사의학)
Journal Title
Journal of Korean Medical Science
Issued Date
2010
Volume
25
Issue
12
Keyword
Mycobacterium tuberculosisIS6110-RFLPSpoligotypingBeijing FamilyK Strain
Abstract
The Beijing family of Mycobacterium tuberculosis has been emerging in the world.
However, there are few nationwide data of genotypic distribution in Korea. This study
aimed to identify the genotypic diversity of clinical isolates of M. tuberculosis and to
demonstrate the population of Beijing family in Korea. We collected 96 clinical M.
tuberculosis isolates from 11 university hospitals nationwide in Korea from 2008 to
2009. We observed 24 clusters in IS6110-RFLP analysis and 19 patterns in
spoligotyping. Seventy-five isolates were confirmed to be Beijing family. Two isolates
of the K strain and 12 isolates of the K family strain were also found. We found that
drug resistance phenotypes were more strongly associated with Beijing family than
non-Beijing family (P=0.003). This study gives an overview of the distribution of
genotypes of M. tuberculosis in Korea. These findings indicate that we have to pay
more attention to control of M. tuberculosis strains associated with the Beijing family.
Keimyung Author(s)(Kor)
류남희
Publisher
School of Medicine
Citation
Go Eun Choi et al. (2010). IS6110-Restriction Fragment Length Polymorphism and Spoligotyping Analysis of Mycobacterium tuberculosis Clinical Isolates for Investigating Epidemiologic Distribution in Korea. Journal of Korean Medical Science, 25(12), 1716–1721. doi: 10.3346/jkms.2010.25.12.1716
Type
Article
ISSN
1011-8934
DOI
10.3346/jkms.2010.25.12.1716
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34110
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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