Clinical findings and outcomes in patients with possible usual interstitial pneumonia

Jin Wook LeeEsmeralda ShehuJuarda GjonbratajYoung Eun BahnByung Hak RhoMi-Young LeeWon-Il Choi
Dept. of Preventive Medicine (예방의학); Dept. of Internal Medicine (내과학); Dept. of Radiology (영상의학)
Issue Date
Respiratory Medicine, Vol.109(4) : 510-516, 2015
Background: Patients with possible usual interstitial pneumonia (UIP) constitute a substantialn group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern. Methods: We evaluated 62 patients with possible UIP and 544 patients with the UIP pattern. Both groups were diagnosed by clinical characteristics and high-resolution computed tomography (HRCT) findings. Two radiologists performed radiological evaluation based on the new idiopathic pulmonary fibrosis (IPF) guidelines. Two risk-stratification methods were used to compare UIP pattern and possible UIP patients. Results: The groups had similar demographic and clinical characteristics. Pulmonary function tests revealed no significant differences in lung volumes between the 2 groups. However, DLCO was significantly lower with the UIP pattern than with possible UIP (p=0.004). Multivariate analysis showed age, sex, and carbon monoxide diffusing capacity (DLCO) as important independent variables for survival. The UIP HRCT pattern did not affect survival (hazard ratio, 0.83; 95% confidence interval, 0.51-1.24; p=0.32). Possible UIP was not associated with prognosis when independent predictors for survival rate and propensity score were considered. In the case-control study, the 3-year survival rate was 44.6% in the UIP pattern group and 56.8% in the possible UIP group (p=0.16).
Idiopathic pulmonaryfibrosisPrognosisHRCT
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
Keimyung Author(s)
이미영; 최원일; 노병학
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