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Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells

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Affiliated Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Journal Title
Toxicol In Vitro
ISSN
0887-2333
Issued Date
2009
Keyword
NaringeninU937ApoptosisBcl-2MMP
Abstract
Naringenin, a naturally occurring citrus flavonone, has shown cytotoxicity in various human cancer cell
lines as well as inhibitory effects on tumor growth and there is increasing interest in its therapeutic
applications. In this study, the effect of ectopic Bcl-2 expression on naringenin-induced apoptosis was
investigated. We found that Bcl-2 overexpression markedly protected human leukemia U937 cells from
time- and dose-dependent induction of apoptosis by naringenin, as did caspase-3 and caspase-9 inhibi-
tors. Additionally, Bcl-2 overexpression attenuated naringenin-induced Bax translocation and cytosolic
release of cytochrome c. Our results also indicated that co-administration of HA14-1 and naringenin
increased apoptosis in Bcl-2 overexpressing U937 cells by restoring mitochondrial dysfunction and acti-
vation of caspase-9 and caspase-3, as well as by cleavage of poly (ADP-ribose) polymerase. Taken
together, these observations indicate that Bcl-2 confers apoptosis resistance to naringenin by inhibiting
a mitochondrial amplification step in U937 cells.
2008 Elsevier Ltd. All rights reserved. Keywords:
Naringenin
U937
Apoptosis
Bcl-2
MMP
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Cheng-Yun Jin et al. (2009). Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. Toxicol In Vitro, 23(2), 259–265. doi: 10.1016/j.tiv.2008.12.005
Type
Article
ISSN
0887-2333
DOI
10.1016/j.tiv.2008.12.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34671
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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