Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells

Authors
Cheng-Yun JinCheol ParkJun-Hyuk LeeKyung Tae ChungTaeg Kyu KwonGi-Young KimByung Tae ChoiYung Hyun Choi
Department
Dept. of Immunology (면역학)
Issue Date
2009
Citation
Toxicol In Vitro, Vol.23(2) : 259-265, 2009
ISSN
0887-2333
Abstract
Naringenin, a naturally occurring citrus flavonone, has shown cytotoxicity in various human cancer cell lines as well as inhibitory effects on tumor growth and there is increasing interest in its therapeutic applications. In this study, the effect of ectopic Bcl-2 expression on naringenin-induced apoptosis was investigated. We found that Bcl-2 overexpression markedly protected human leukemia U937 cells from time- and dose-dependent induction of apoptosis by naringenin, as did caspase-3 and caspase-9 inhibi- tors. Additionally, Bcl-2 overexpression attenuated naringenin-induced Bax translocation and cytosolic release of cytochrome c. Our results also indicated that co-administration of HA14-1 and naringenin increased apoptosis in Bcl-2 overexpressing U937 cells by restoring mitochondrial dysfunction and acti- vation of caspase-9 and caspase-3, as well as by cleavage of poly (ADP-ribose) polymerase. Taken together, these observations indicate that Bcl-2 confers apoptosis resistance to naringenin by inhibiting a mitochondrial amplification step in U937 cells. 2008 Elsevier Ltd. All rights reserved. Keywords: Naringenin U937 Apoptosis Bcl-2 MMP
Keywords
NaringeninU937ApoptosisBcl-2MMP
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34671
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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Full Text
http://lps3.linkinghub.elsevier.com.proxy.dsmc.or.kr/retrieve/pii/S0887-2333(08)00289-0
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