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Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells

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Author(s)
Cheng-Yun JinCheol ParkJun-Hyuk LeeKyung Tae ChungTaeg Kyu KwonGi-Young KimByung Tae ChoiYung Hyun Choi
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Toxicol In Vitro
Issued Date
2009
Volume
23
Issue
2
Keyword
NaringeninU937ApoptosisBcl-2MMP
Abstract
Naringenin, a naturally occurring citrus flavonone, has shown cytotoxicity in various human cancer cell
lines as well as inhibitory effects on tumor growth and there is increasing interest in its therapeutic
applications. In this study, the effect of ectopic Bcl-2 expression on naringenin-induced apoptosis was
investigated. We found that Bcl-2 overexpression markedly protected human leukemia U937 cells from
time- and dose-dependent induction of apoptosis by naringenin, as did caspase-3 and caspase-9 inhibi-
tors. Additionally, Bcl-2 overexpression attenuated naringenin-induced Bax translocation and cytosolic
release of cytochrome c. Our results also indicated that co-administration of HA14-1 and naringenin
increased apoptosis in Bcl-2 overexpressing U937 cells by restoring mitochondrial dysfunction and acti-
vation of caspase-9 and caspase-3, as well as by cleavage of poly (ADP-ribose) polymerase. Taken
together, these observations indicate that Bcl-2 confers apoptosis resistance to naringenin by inhibiting
a mitochondrial amplification step in U937 cells.
2008 Elsevier Ltd. All rights reserved. Keywords:
Naringenin
U937
Apoptosis
Bcl-2
MMP
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Cheng-Yun Jin et al. (2009). Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. Toxicol In Vitro, 23(2), 259–265. doi: 10.1016/j.tiv.2008.12.005
Type
Article
ISSN
0887-2333
Source
http://lps3.linkinghub.elsevier.com.proxy.dsmc.or.kr/retrieve/pii/S0887-2333(08)00289-0
DOI
10.1016/j.tiv.2008.12.005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34671
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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