Early Posttransplantation Complication Pathology in the Experimentally Induced Allograft Lung

K.Y. KwonC.K. ParkS.B. ParkY.J. JeonH.C. Kim
Dept. of Pathology (병리학); Dept. of Internal Medicine (내과학); Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Issue Date
Transplantation Proceedings, Vol.30(7) : 3351-3353, 1998
LUNG allografts are susceptible to a wide variety of airway mediated and vascular mediated insults begin- ning at graft revascularization. 1 Early changes can be observed during the immediate postoperative and periop- erative periods. The survival rate of transplanted lungs is limited by early posttransplantation complications and later obliterative bronchiolitis. 2 Early graft failure and other complications continue to be a major clinical problem after lung transplantation. The aim of this study is to investigate early clinicopathologic changes in the experimentally in- duced allograft lungs. MATERIALS AND METHODS Fifty Korean adult dogs received single allograft lung transplanta- tions (25 pairs). Pathologic evaluation for 22 of the 25 cases was available. All of the autopsy cases (n 5 13) died immediately or soon after transplantation while the others (n 5 9) were sacrificed to investigate the early complication pathology (Table 1). The donor lungs had been preserved for 20 hours at 10°C after flushing with low-potassium dextran glucose (n 5 12), modified Euro- Collins (n 5 9), or University of Wisconsin (n 5 1) solution. Using the transplanted lungs, we investigated gross and light microscopic changes. All lung tissues were fixed in 10% buffered formalin, paraffin-embedded, sectioned 4 mm in thickness. The specimens were then stained with hematoxylin-eosin, trichrome, Gomori’s methenamine silver, Gram’s and Ziehl–Neelsen stains. Cultures were not performed. RESULTS Clinical Features The clinical features of the early posttransplantation com- plications were primary graft failures (4), implantation
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Keimyung Author(s)
권건영; 박성배; 전영준; 김현철; 박창권
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