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Early Posttransplantation Complication Pathology in the Experimentally Induced Allograft Lung

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Author(s)
K.Y. KwonC.K. ParkS.B. ParkY.J. JeonH.C. Kim
Keimyung Author(s)
Kwon, Kun YoungPark, Sung BaeJeon, Young JuneKim, Hyun ChulPark, Chang Kwon
Department
Dept. of Pathology (병리학)
Dept. of Internal Medicine (내과학)
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Transplantation Proceedings
Issued Date
1998
Volume
30
Issue
7
Abstract
LUNG allografts are susceptible to a wide variety of
airway mediated and vascular mediated insults begin-
ning at graft revascularization.
1
Early changes can be
observed during the immediate postoperative and periop-
erative periods. The survival rate of transplanted lungs is
limited by early posttransplantation complications and later
obliterative bronchiolitis.
2
Early graft failure and other
complications continue to be a major clinical problem after
lung transplantation. The aim of this study is to investigate
early clinicopathologic changes in the experimentally in-
duced allograft lungs.
MATERIALS AND METHODS
Fifty Korean adult dogs received single allograft lung transplanta-
tions (25 pairs). Pathologic evaluation for 22 of the 25 cases was
available. All of the autopsy cases (n 5 13) died immediately or
soon after transplantation while the others (n 5 9) were sacrificed
to investigate the early complication pathology (Table 1). The
donor lungs had been preserved for 20 hours at 10°C after flushing
with low-potassium dextran glucose (n 5 12), modified Euro-
Collins (n 5 9), or University of Wisconsin (n 5 1) solution. Using
the transplanted lungs, we investigated gross and light microscopic
changes. All lung tissues were fixed in 10% buffered formalin,
paraffin-embedded, sectioned 4 mm in thickness. The specimens
were then stained with hematoxylin-eosin, trichrome, Gomori’s
methenamine silver, Gram’s and Ziehl–Neelsen stains. Cultures
were not performed.
RESULTS
Clinical Features
The clinical features of the early posttransplantation com-
plications were primary graft failures (4), implantation
Keimyung Author(s)(Kor)
권건영
박성배
전영준
김현철
박창권
Publisher
School of Medicine
Citation
K.Y. Kwon et al. (1998). Early Posttransplantation Complication Pathology in the Experimentally Induced Allograft Lung. Transplantation Proceedings, 30(7), 3351–3353. doi: 10.1016/S0041-1345(98)01058-6
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134598010586?via%3Dihub
DOI
10.1016/S0041-1345(98)01058-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34678
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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