Production of Oxygen Free Radicals and of Hemolysis by Cyclosporine

Authors
C.S. KwakK.C. MunS.I. Suh
Department
Dept. of Biochemistry (생화학); Dept. of Microbiology (미생물학); Institute for Medical Science (의과학연구소)
Issue Date
2002
Citation
Transplantation Proceedings, Vol.34(7) : 2654-2655, 2002
ISSN
0041-1345
Abstract
HEMOLYSIS is one side effect of cyclosporine (CsA)1,2 the incidence of which has been reported to be approximately 10%.2 Hemolysis may indicate ischemic vascular damage associated with CsA nephrotoxicity,2 which is the most common and clinically important side effect of CsA.3 A report by Azuma et al1 suggests that CsA-induced hemolysis results from increased production of free radical species caused by CsA.Melatonin, which acts as an efficient free radical scavenger,4,5 may protect against CsA-induced hemolysis. To ascertain whether CsA directly stimulates the production of superoxide anions we mea- sured production of these moieties in purified mitochondria and in human erythrocytes (RBCs) incubated with CsA and melatonin.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34693
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
Keimyung Author(s)
곽춘식; 문교철; 서성일
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134502034632?via%3Dihub
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