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Production of Oxygen Free Radicals and of Hemolysis by Cyclosporine

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Author(s)
곽춘식문교철서성일
Alternative Author(s)
Kwak, Chun SikMun, Kyo CheolSuh, Seong Il
Publication Year
2002
Abstract
HEMOLYSIS is one side effect of cyclosporine
(CsA)1,2
the incidence of which has been reported to
be approximately 10%.2
Hemolysis may indicate ischemic
vascular damage associated with CsA nephrotoxicity,2 which is the most common and clinically important side
effect of CsA.3
A report by Azuma et al1
suggests that
CsA-induced hemolysis results from increased production
of free radical species caused by CsA.Melatonin, which acts
as an efficient free radical scavenger,4,5
may protect against
CsA-induced hemolysis. To ascertain whether CsA directly
stimulates the production of superoxide anions we mea-
sured production of these moieties in purified mitochondria
and in human erythrocytes (RBCs) incubated with CsA and
melatonin.
Department
Dept. of Biochemistry (생화학)
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Publisher
School of Medicine
Citation
Transplantation Proceedings, Vol.34(7) : 2654-2655, 2002
Type
Article
ISSN
0041-1345
DOI
10.1016/S0041-1345(02)03463-2
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34693
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