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Production of Oxygen Free Radicals and of Hemolysis by Cyclosporine

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Author(s)
C.S. KwakK.C. MunS.I. Suh
Keimyung Author(s)
Kwak, Chun SikMun, Kyo CheolSuh, Seong Il
Department
Dept. of Biochemistry (생화학)
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
Transplantation Proceedings
Issued Date
2002
Volume
34
Issue
7
Abstract
HEMOLYSIS is one side effect of cyclosporine
(CsA)1,2
the incidence of which has been reported to
be approximately 10%.2
Hemolysis may indicate ischemic
vascular damage associated with CsA nephrotoxicity,2 which is the most common and clinically important side
effect of CsA.3
A report by Azuma et al1
suggests that
CsA-induced hemolysis results from increased production
of free radical species caused by CsA.Melatonin, which acts
as an efficient free radical scavenger,4,5
may protect against
CsA-induced hemolysis. To ascertain whether CsA directly
stimulates the production of superoxide anions we mea-
sured production of these moieties in purified mitochondria
and in human erythrocytes (RBCs) incubated with CsA and
melatonin.
Keimyung Author(s)(Kor)
곽춘식
문교철
서성일
Publisher
School of Medicine
Citation
C.S. Kwak et al. (2002). Production of Oxygen Free Radicals and of Hemolysis by Cyclosporine. Transplantation Proceedings, 34(7), 2654–2655. doi: 10.1016/S0041-1345(02)03463-2
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134502034632?via%3Dihub
DOI
10.1016/S0041-1345(02)03463-2
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34693
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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