Comparison of Canine Single and Sequential Bilateral Lung Transplant Model for Lung Preservation Study

Authors
D.Y. KeumC.K. ParkK.Y. KwonW.K. ParkS.K. Zeon
Department
Dept. of Pathology (병리학); Dept. of Thoracic & Cardiovascular Surgery (흉부외과학); Dept. of Nuclear Medicine (핵의학); Dept. of Medical Education (의학교육학)
Issue Date
2004
Citation
Transplantation Proceedings, Vol.36(8) : 2403-2405, 2004
ISSN
0041-1345
Abstract
The purpose of this study was to compare canine sequential bilateral lung transplantation (SBLT) with left single lung transplant (LSLT) models. After 24 hours of lung preservation with low potassium/dextran glucose (LPDG) solution, seven SBLT procedures were performed using mongrel dogs. The comparative group including nine cases of LSLT. After completion of each transplant, the dogs were maintained on a ventilator for 3 hours. Thereafter serial hemodynamics were evaluated with recipients with chest X-ray, com- puted tomography, and lung perfusion scan checked at 2 hours after transplantation. Pathological evaluations were also performed. Five of seven SBLT successfully completed the whole assessment, all LSLT survived. In SBLT, pulmonary arterial pressure and pulmonary vascular resistance were significantly elevated, but recovered 3 hours after reperfusion. The ultrastructural aspects of alveolae and pulmonary artery endothelium showed a reversible mild injury 24 hours after lung preservation and reperfusion. The present study suggests that the canine SBLT model using LPDG solution provides an excellent preservation effect and is more physiological as the dog is completely dependent on the function of the transplanted lung.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34715
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Keimyung Author(s)
권건영; 금동윤; 박창권; 전석길; 박원균
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134504008437?via%3Dihub
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