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Comparison of Canine Single and Sequential Bilateral Lung Transplant Model for Lung Preservation Study

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Author(s)
D.Y. KeumC.K. ParkK.Y. KwonW.K. ParkS.K. Zeon
Keimyung Author(s)
Kwon, Kun YoungKeum, Dong YoonPark, Chang KwonZeon, Seok KilPark, Won Kyun
Department
Dept. of Pathology (병리학)
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Dept. of Nuclear Medicine (핵의학)
Dept. of Medical Education (의학교육학)
Journal Title
Transplantation Proceedings
Issued Date
2004
Volume
36
Issue
8
Abstract
The purpose of this study was to compare canine sequential bilateral lung transplantation
(SBLT) with left single lung transplant (LSLT) models. After 24 hours of lung preservation
with low potassium/dextran glucose (LPDG) solution, seven SBLT procedures were
performed using mongrel dogs. The comparative group including nine cases of LSLT.
After completion of each transplant, the dogs were maintained on a ventilator for 3 hours.
Thereafter serial hemodynamics were evaluated with recipients with chest X-ray, com-
puted tomography, and lung perfusion scan checked at 2 hours after transplantation.
Pathological evaluations were also performed. Five of seven SBLT successfully completed
the whole assessment, all LSLT survived. In SBLT, pulmonary arterial pressure and
pulmonary vascular resistance were significantly elevated, but recovered 3 hours after
reperfusion. The ultrastructural aspects of alveolae and pulmonary artery endothelium
showed a reversible mild injury 24 hours after lung preservation and reperfusion. The
present study suggests that the canine SBLT model using LPDG solution provides an
excellent preservation effect and is more physiological as the dog is completely dependent
on the function of the transplanted lung.
Keimyung Author(s)(Kor)
권건영
금동윤
박창권
전석길
박원균
Publisher
School of Medicine
Citation
D.Y. Keum et al. (2004). Comparison of Canine Single and Sequential Bilateral Lung Transplant Model for Lung Preservation Study. Transplantation Proceedings, 36(8), 2403–2405. doi: 10.1016/j.transproceed.2004.07.061
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134504008437?via%3Dihub
DOI
10.1016/j.transproceed.2004.07.061
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34715
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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