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Comparison of Canine Single and Sequential Bilateral Lung Transplant Model for Lung Preservation Study

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Author(s)
D.Y. KeumC.K. ParkK.Y. KwonW.K. ParkS.K. Zeon
Publication Year
2004
Abstract
The purpose of this study was to compare canine sequential bilateral lung transplantation
(SBLT) with left single lung transplant (LSLT) models. After 24 hours of lung preservation
with low potassium/dextran glucose (LPDG) solution, seven SBLT procedures were
performed using mongrel dogs. The comparative group including nine cases of LSLT.
After completion of each transplant, the dogs were maintained on a ventilator for 3 hours.
Thereafter serial hemodynamics were evaluated with recipients with chest X-ray, com-
puted tomography, and lung perfusion scan checked at 2 hours after transplantation.
Pathological evaluations were also performed. Five of seven SBLT successfully completed
the whole assessment, all LSLT survived. In SBLT, pulmonary arterial pressure and
pulmonary vascular resistance were significantly elevated, but recovered 3 hours after
reperfusion. The ultrastructural aspects of alveolae and pulmonary artery endothelium
showed a reversible mild injury 24 hours after lung preservation and reperfusion. The
present study suggests that the canine SBLT model using LPDG solution provides an
excellent preservation effect and is more physiological as the dog is completely dependent
on the function of the transplanted lung.
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