계명대학교 의학도서관 Repository

Effect of Melatonin on Antioxidant Status in the Plasma of Cyclosporine-Treated Rats

Metadata Downloads
Author(s)
Y.H. KimS.H. LeeK.C. Mun
Publication Year
2002
Abstract
Oxygen free radicals contribute to cyclosporine (CsA)–induced toxicity.¹,² Aerobic cells are protected against damage by active oxygen moieties by several antioxidants, including enzymes, vitamin C, vitamin E, and melatonin.³,⁴ Melatonin is a free radical scavenger⁴,5 that has stimulatory effects on superoxide dismutase and glutathione peroxidase.5 In addition to its scavenging effect on free radicals, melatonin may increase total antioxidant status by inducing superoxide dismutase and glutathione peroxidase.

To test this hypothesis, the antioxidant status and three well-known antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and catalase, were measured in the plasma of CsA- and melatonin-treated rats.
Department
Dept. of Biochemistry (생화학)
Kidney Institute (신장연구소)
Publisher
School of Medicine
Citation
Transplantation proceedings, Vol.34(7) : 2652-2653, 2002
Type
Article
ISSN
0041-1345
DOI
10.1016/S0041-1345(02)03462-0
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34738
Authorize & License
  • AuthorizeOpen
  • EmbargoForever
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.