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Effect of Melatonin on Antioxidant Status in the Plasma of Cyclosporine-Treated Rats

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Author(s)
Y.H. KimS.H. LeeK.C. Mun
Keimyung Author(s)
Kim, You HeeMun, Kyo Cheol
Department
Dept. of Biochemistry (생화학)
Kidney Institute (신장연구소)
Journal Title
Transplantation proceedings
Issued Date
2002
Volume
34
Issue
7
Abstract
Oxygen free radicals contribute to cyclosporine (CsA)–induced toxicity.¹,² Aerobic cells are protected against damage by active oxygen moieties by several antioxidants, including enzymes, vitamin C, vitamin E, and melatonin.³,⁴ Melatonin is a free radical scavenger⁴,5 that has stimulatory effects on superoxide dismutase and glutathione peroxidase.5 In addition to its scavenging effect on free radicals, melatonin may increase total antioxidant status by inducing superoxide dismutase and glutathione peroxidase.

To test this hypothesis, the antioxidant status and three well-known antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and catalase, were measured in the plasma of CsA- and melatonin-treated rats.
Keimyung Author(s)(Kor)
김여희
문교철
Publisher
School of Medicine
Citation
Y.H. Kim et al. (2002). Effect of Melatonin on Antioxidant Status in the Plasma of Cyclosporine-Treated Rats. Transplantation proceedings, 34(7), 2652–2653. doi: 10.1016/S0041-1345(02)03462-0
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134502034620?via%3Dihub
DOI
10.1016/S0041-1345(02)03462-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34738
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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