Effects of Cyclosporine on the Production of the Reactive Oxygen Species in the Glial Cells

Authors
K.C. MunK.T. LeeH.J. ChoiK.B. JinS.Y. HanS.B. ParkH.C. KimE.Y. HaY.H. Kim
Department
Dept. of Biochemistry (생화학); Dept. of Internal Medicine (내과학); Kidney Institute (신장연구소)
Issue Date
2008
Citation
Transplantation Proceedings, Vol.40(8) : 2742~2743-2742~2743, 2008
ISSN
0041-1345
Abstract
Objectives After organ transplantation, some patients suffer mild neurological symptoms such as tremor to severe complications including seizures and encephalopathy. Among the immunosuppressants, cyclosporine (CsA) can induce neurological side effects. However, the mechanisms of encephalopathy by CsA are not fully understood. We measured the production of reactive oxygen species (ROS) in the glioma cells after CsA treatment. Methods CsA (2.5 mmol/L) added to glioma cells was incubated for 60 minutes at 37°C. ROS production was evaluated by measuring the fluorescent product from the oxidation of an oxidant-sensitive 2′,7′-dichlorofluorescin using VICTOR3 multilabel counter. Results CsA resulted in ROS production by glioma cells. The ROS production increased with the time of exposure to CsA. Conclusions These findings indicated that CsA may contribute to neurological side effects via ROS production.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34743
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Kidney Institute (신장연구소)
Keimyung Author(s)
문교철; 하은영; 김여희; 진규복; 한승엽; 박성배; 김현철
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134508010579?via%3Dihub
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