계명대학교 의학도서관 Repository

Effects of Cyclosporine on the Production of the Reactive Oxygen Species in the Glial Cells

Metadata Downloads
Author(s)
K.C. MunK.T. LeeH.J. ChoiK.B. JinS.Y. HanS.B. ParkH.C. KimE.Y. HaY.H. Kim
Keimyung Author(s)
Mun, Kyo CheolHa, Eun YoungKim, You HeeJin, Kyu BokHan, Seung YeupPark, Sung BaeKim, Hyun Chul
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Transplantation Proceedings
Issued Date
2008
Volume
40
Issue
8
Abstract
Objectives

After organ transplantation, some patients suffer mild neurological symptoms such as tremor to severe complications including seizures and encephalopathy. Among the immunosuppressants, cyclosporine (CsA) can induce neurological side effects. However, the mechanisms of encephalopathy by CsA are not fully understood. We measured the production of reactive oxygen species (ROS) in the glioma cells after CsA treatment.

Methods

CsA (2.5 mmol/L) added to glioma cells was incubated for 60 minutes at 37°C. ROS production was evaluated by measuring the fluorescent product from the oxidation of an oxidant-sensitive 2′,7′-dichlorofluorescin using VICTOR3 multilabel counter.

Results

CsA resulted in ROS production by glioma cells. The ROS production increased with the time of exposure to CsA.

Conclusions

These findings indicated that CsA may contribute to neurological side effects via ROS production.
Keimyung Author(s)(Kor)
문교철
하은영
김여희
진규복
한승엽
박성배
김현철
Publisher
School of Medicine
Citation
K.C. Mun et al. (2008). Effects of Cyclosporine on the Production of the Reactive Oxygen Species in the Glial Cells. Transplantation Proceedings, 40(8), 2742~2743-2742~2743. doi: 10.1016/j.transproceed.2008.08.007
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134508010579?via%3Dihub
DOI
10.1016/j.transproceed.2008.08.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34743
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.