Oxidative Damage in Renal Transplant Patients

Authors
Y.H. KimK.C. MunS.S. LeeS.H. SeoC.S. KwakS.B. ParkH.C. Kim
Department
Dept. of Biochemistry (생화학); Dept. of Internal Medicine (내과학)
Issue Date
2000
Citation
Transplantation Proceedings, Vol.32(7) : 1777-1778, 2000
ISSN
0041-1345
Abstract
Exposure to oxygen free radicals is responsible for damage to cells and tissues in vivo, where it may cause kidney disease1 and several complications in patients with end-stage renal disease such as atherosclerosis,2 anemia,3 and infection.4 Renal transplant patients are also subject to oxidative cell damage, including vascular thrombosis and adverse effects on early graft function.5 and 6 Aerobic cells are protected by several antioxidants7 against damage by active oxygens, including three well-known biologic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase.7 Superoxide is converted to hydrogen peroxide by the action of superoxide dismutase.7 And hydrogen peroxide is disposed of by the action of glutathione peroxidase or catalase.7 The alterations in the activity of these antioxidant enzymes contributes to the damage in patients with end-stage renal disease.2, 3 and 4 In this study, the levels of malondialdehyde, which is an indirect index of oxidative injury,8 superoxide dismutase, catalase, and glutathione peroxidase were measure in plasma from renal transplant patients.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34759
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
문교철; 곽춘식; 김여희; 박성배; 김현철
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134500013804?via%3Dihub
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE