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Oxidative Damage in Renal Transplant Patients

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Author(s)
Y.H. KimK.C. MunS.S. LeeS.H. SeoC.S. KwakS.B. ParkH.C. Kim
Keimyung Author(s)
Mun, Kyo CheolKwak, Chun SikKim, You HeePark, Sung BaeKim, Hyun Chul
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Journal Title
Transplantation Proceedings
Issued Date
2000
Volume
32
Issue
7
Abstract
Exposure to oxygen free radicals is responsible for damage to cells and tissues in vivo, where it may cause kidney disease1 and several complications in patients with end-stage renal disease such as atherosclerosis,2 anemia,3 and infection.4 Renal transplant patients are also subject to oxidative cell damage, including vascular thrombosis and adverse effects on early graft function.5 and 6

Aerobic cells are protected by several antioxidants7 against damage by active oxygens, including three well-known biologic antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase.7 Superoxide is converted to hydrogen peroxide by the action of superoxide dismutase.7 And hydrogen peroxide is disposed of by the action of glutathione peroxidase or catalase.7 The alterations in the activity of these antioxidant enzymes contributes to the damage in patients with end-stage renal disease.2, 3 and 4

In this study, the levels of malondialdehyde, which is an indirect index of oxidative injury,8 superoxide dismutase, catalase, and glutathione peroxidase were measure in plasma from renal transplant patients.
Keimyung Author(s)(Kor)
문교철
곽춘식
김여희
박성배
김현철
Publisher
School of Medicine
Citation
Y.H. Kim et al. (2000). Oxidative Damage in Renal Transplant Patients. Transplantation Proceedings, 32(7), 1777–1778. doi: 10.1016/S0041-1345(00)01380-4
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134500013804?via%3Dihub
DOI
10.1016/S0041-1345(00)01380-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34759
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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