The Beneficial Effect of Melatonin for Cyclosporine Hepatotoxicity in Rats

Authors
C.S. KwakK.C. Mun
Department
Dept. of Biochemistry (생화학)
Issue Date
2000
Citation
Transplantation Proceedings, Vol.32(7) : 2009-2010, 2000
ISSN
0041-1345
Abstract
In humans the immunosuppressive drug cyclosporine A (CsA) has been used successfully in organ transplantation and in the treatment of autoimmune disorders.1 CsA, however, causes side effects that occur mainly in the kidney2 and 3 but also in the liver.1 and 2 Although, the mechanisms leading to the hepatic side effects are not fully understood, several reports have strongly suggested that reactive oxygen production is a common mechanism of CsA toxicity.1 Melatonin, a pineal secretory product, has been reported to have antioxidant properties in addition to its known hormonal activities.4, 5, 6 and 7 Melatonin acts as a highly efficient free radical scavenger that protects cells from damage by oxygen free radicals.4, 5, 6 and 7 Melatonin may have a protective effect on the deteriorated hepatic function that results from oxygen free radicals in the CsA-induced hepatotoxicity. To test this hypothesis, CsA hepatotoxicity was induced by subcutaneous injection of CsA for 14 days. Protection by melatonin was done by the injection with melatonin intraperitoneally at the time of CsA injection. Total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyl transferase (γ-GT) levels in serum were measured to estimate hepatic function. Malondialdehyde, which gives an indirect index of oxidative injury,8 was also measured.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34767
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
Keimyung Author(s)
곽춘식; 문교철
Full Text
https://www.sciencedirect.com/science/article/pii/S0041134500015359?via%3Dihub
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