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The Beneficial Effect of Melatonin for Cyclosporine Hepatotoxicity in Rats

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Author(s)
C.S. KwakK.C. Mun
Keimyung Author(s)
Kwak, Chun SikMun, Kyo Cheol
Department
Dept. of Biochemistry (생화학)
Journal Title
Transplantation Proceedings
Issued Date
2000
Volume
32
Issue
7
Abstract
In humans the immunosuppressive drug cyclosporine A (CsA) has been used successfully in organ transplantation and in the treatment of autoimmune disorders.1 CsA, however, causes side effects that occur mainly in the kidney2 and 3 but also in the liver.1 and 2 Although, the mechanisms leading to the hepatic side effects are not fully understood, several reports have strongly suggested that reactive oxygen production is a common mechanism of CsA toxicity.1

Melatonin, a pineal secretory product, has been reported to have antioxidant properties in addition to its known hormonal activities.4, 5, 6 and 7 Melatonin acts as a highly efficient free radical scavenger that protects cells from damage by oxygen free radicals.4, 5, 6 and 7 Melatonin may have a protective effect on the deteriorated hepatic function that results from oxygen free radicals in the CsA-induced hepatotoxicity.

To test this hypothesis, CsA hepatotoxicity was induced by subcutaneous injection of CsA for 14 days. Protection by melatonin was done by the injection with melatonin intraperitoneally at the time of CsA injection. Total protein, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ-glutamyl transferase (γ-GT) levels in serum were measured to estimate hepatic function. Malondialdehyde, which gives an indirect index of oxidative injury,8 was also measured.
Keimyung Author(s)(Kor)
곽춘식
문교철
Publisher
School of Medicine
Citation
C.S. Kwak and K.C. Mun. (2000). The Beneficial Effect of Melatonin for Cyclosporine Hepatotoxicity in Rats. Transplantation Proceedings, 32(7), 2009–2010. doi: 10.1016/S0041-1345(00)01535-9
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134500015359?via%3Dihub
DOI
10.1016/S0041-1345(00)01535-9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34767
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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