Does the Mean Arterial Pressure Influence Mortality Rate in Patients
with Acute Hypoxemic Respiratory Failure under Mechanical Ventilation?
- Juarda Gjonbrataj; Hyun Jung Kim; Hye In Jung; Won-Il Choi
- Dept. of Internal Medicine (내과학)
- Issue Date
- Tuberculosis and Respiratory Diseases, Vol.78(2) : 85-91, 2015
- Background: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended.
However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the
influence of MAP over the first 24 hours after intensive care unit (ICU) admission on the mortality rate at 60 days post-
admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation.
Methods: This prospective, multicenter study included 22 ICUs and compared the mortality and clinical outcomes in
patients showing acute hypoxemic respiratory failure with high (75–90 mm Hg) and low (65–74.9 mm Hg) MAPs over
the first 24 hours of admission to the ICU.
Results: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65–90 mm Hg over
the first 24 hours of admission to the ICU. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups
were not significantly different. The ICU days, hospital days, and 60-day mortality rate did not differ between the groups.
Conclusion: In the first 24 hours of ICU admission, MAP range between 65 and 90 mm Hg in patients with acute
hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.
Keywords: Arterial Pressure; Respiratory Insufficiency; Respiration, Artificial
- Arterial Pressure; Respiratory Insufficiency; Respiration; Artificial
- Appears in Collections:
- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
- Keimyung Author(s)
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