Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

Authors
Yong Shik KwonHye In JungHyun Jung KimJin Wook LeeWon-Il ChoiJin Young KimByung Hak RhoHye Won LeeKun Young Kwon
Department
Dept. of Internal Medicine (내과학); Dept. of Pathology (병리학); Dept. of Radiology (영상의학)
Issue Date
2013
Citation
Tuberculosis and Respiratory Diseases, Vol.75(3) : 116-119, 2013
ISSN
1738-3536
Abstract
Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma. Keywords: Sarcoidosis; Lymphatic Diseases; Neck; Immunohistochemistry
Keywords
SarcoidosisLymphatic DiseasesNeckImmunohistochemistry
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34780
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
Keimyung Author(s)
최원일; 권건영; 이혜원; 노병학
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