Dept. of Internal Medicine (내과학); Dept. of Pathology (병리학); Dept. of Radiology (영상의학)
Tuberculosis and Respiratory Diseases, Vol.75(3) : 116-119, 2013
Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in
neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of
a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass
showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal
infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal
abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma.
However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These
immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis
can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry
may support the diagnosis of sarcoidosis and characterization of granuloma.
Keywords: Sarcoidosis; Lymphatic Diseases; Neck; Immunohistochemistry