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Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

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Author(s)
Yong Shik KwonHye In JungHyun Jung KimJin Wook LeeWon-Il ChoiJin Young KimByung Hak RhoHye Won LeeKun Young Kwon
Keimyung Author(s)
Choi, Won IlKwon, Kun YoungLee, Hye WonRho, Byung Hak
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Radiology (영상의학)
Journal Title
Tuberculosis and Respiratory Diseases
Issued Date
2013
Volume
75
Issue
3
Keyword
SarcoidosisLymphatic DiseasesNeckImmunohistochemistry
Abstract
Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in
neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of
a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass
showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal
infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal
abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma.
However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These
immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis
can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry
may support the diagnosis of sarcoidosis and characterization of granuloma.
Keywords: Sarcoidosis; Lymphatic Diseases; Neck; Immunohistochemistry
Keimyung Author(s)(Kor)
최원일
권건영
이혜원
노병학
Publisher
School of Medicine
Citation
Yong Shik Kwon et al. (2013). Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report. Tuberculosis and Respiratory Diseases, 75(3), 116–119. doi: 10.4046/trd.2013.75.3.116
Type
Article
ISSN
1738-3536
DOI
10.4046/trd.2013.75.3.116
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34780
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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