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LONG-TERM RESULTS OF MEDICAL TREATMENT IN BENIGN PROSTATIC HYPERPLASIA

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Author(s)
김천일장혁수김병훈박철희
Alternative Author(s)
Kim, Chun IlChang, Hyuk SooKim, Byung HoonPark, Choal Hee
Publication Year
2006
Abstract
Objectives

In real-life clinical practice, we determined the incidence of acute urinary retention (AUR) and benign prostatic hyperplasia (BPH)-related surgery in patients with BPH who received alpha-adrenergic receptor blocker (α-blocker) and/or 5-alpha-reductase inhibitor combination treatment.

Methods

This retrospective study enrolled 341 patients with BPH who were prescribed an α-blocker and/or a 5-alpha-reductase inhibitor as their first treatment from January 1997 to June 1999. Using follow-up data from a 6 to 8-year period, we calculated the incidence of AUR and BPH-related surgery in the α-blocker-only group and in the combination group.

Results

Of the 341 patients, 192 were in the α-blocker group and 149 were in the combination group. Of these, 17.7% in the α-blocker group and 12.1% in the combination group experienced AUR (P <0.05). BPH-related surgery was performed in 10.9% of the α-blocker-only group and 6.0% of the combination group (P <0.05). The incidence of AUR and BPH-related surgery was reduced by 32.3% and 48.9% when the prostate volume was larger than 35 g and by 49.4% and 60.6% when the prostate-specific antigen level was greater than 2.0 ng/mL, respectively, in the combination group compared with the corresponding values in the α-blocker group.

Conclusions

Real-life clinical practice showed that long-term combination treatment with α-blockers and 5-alpha-reductase inhibitors reduced the risk of BPH progression, such as AUR or BPH-related surgery, compared with α-blocker-only treatment.
Department
Dept. of Urology (비뇨의학)
Publisher
School of Medicine
Citation
Urology, Vol.68(5) : 1015-1019, 2006
Type
Article
ISSN
0090-4295
DOI
10.1016/j.urology.2006.06.003
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34794
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