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LONG-TERM RESULTS OF MEDICAL TREATMENT IN BENIGN PROSTATIC HYPERPLASIA

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Author(s)
CHUN IL KIMHYUK SOO CHANGBYOUNG KUN KIMCHOAL HEE PARK
Keimyung Author(s)
Kim, Chun IlChang, Hyuk SooKim, Byung HoonPark, Choal Hee
Department
Dept. of Urology (비뇨의학)
Journal Title
Urology
Issued Date
2006
Volume
68
Issue
5
Abstract
Objectives

In real-life clinical practice, we determined the incidence of acute urinary retention (AUR) and benign prostatic hyperplasia (BPH)-related surgery in patients with BPH who received alpha-adrenergic receptor blocker (α-blocker) and/or 5-alpha-reductase inhibitor combination treatment.

Methods

This retrospective study enrolled 341 patients with BPH who were prescribed an α-blocker and/or a 5-alpha-reductase inhibitor as their first treatment from January 1997 to June 1999. Using follow-up data from a 6 to 8-year period, we calculated the incidence of AUR and BPH-related surgery in the α-blocker-only group and in the combination group.

Results

Of the 341 patients, 192 were in the α-blocker group and 149 were in the combination group. Of these, 17.7% in the α-blocker group and 12.1% in the combination group experienced AUR (P <0.05). BPH-related surgery was performed in 10.9% of the α-blocker-only group and 6.0% of the combination group (P <0.05). The incidence of AUR and BPH-related surgery was reduced by 32.3% and 48.9% when the prostate volume was larger than 35 g and by 49.4% and 60.6% when the prostate-specific antigen level was greater than 2.0 ng/mL, respectively, in the combination group compared with the corresponding values in the α-blocker group.

Conclusions

Real-life clinical practice showed that long-term combination treatment with α-blockers and 5-alpha-reductase inhibitors reduced the risk of BPH progression, such as AUR or BPH-related surgery, compared with α-blocker-only treatment.
Keimyung Author(s)(Kor)
김천일
장혁수
김병훈
박철희
Publisher
School of Medicine
Citation
CHUN IL KIM et al. (2006). LONG-TERM RESULTS OF MEDICAL TREATMENT IN BENIGN PROSTATIC HYPERPLASIA. Urology, 68(5), 1015–1019. doi: 10.1016/j.urology.2006.06.003
Type
Article
ISSN
0090-4295
Source
https://www.sciencedirect.com/science/article/pii/S0090429506007643?via%3Dihub
DOI
10.1016/j.urology.2006.06.003
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34794
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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