Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity

Authors
Kyung Jin WooYong-Jin JeongHiroyasu InoueJong-Wook ParkTaeg Kyu Kwon
Department
Dept. of Immunology (면역학)
Issue Date
2005
Citation
FEBS Lett, Vol.579(3) : 705-711, 2005
ISSN
0014-5793
Abstract
Chrysin is a natural, biologically active compound extracted from many plants, honey and propolis. It possesses potent anti-inflammation, anti-cancer and anti-oxidation properties. The mechanism by which chrysin suppresses COX-2 expression remains poorly understood. In the present report, we investigated the effect of chrysin on the expression of COX-2 in lipopolysaccharide (LPS)-activated Raw 264.7 cells. Chrysin significantly suppressed the LPS-induced COX-2 protein and mRNA expression in a dose-dependent manner. The ability of chrysin to suppress the expression of the COX-2 was investigated using luciferase reporters controlled by various cis-elements in COX-2 promoter region. Mutational analysis and electrophoretic mobility shift assay verified that nuclear factor for IL-6 was identified as responsible for the chrysin-mediated COX-2 downregulation. These results will provide new insights into the anti-inflammatory and anti-carcinogenic properties of chrysin. 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Keywords: Chrysin; Cyclooxygenase-2; Nuclear factor for IL-6; Macrophage; Lipopolysaccharide
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34839
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
박종욱; 권택규
Full Text
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2004.12.048
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