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Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity

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Affiliated Author(s)
박종욱권택규
Alternative Author(s)
Park, Jong WookKwon, Taeg Kyu
Journal Title
FEBS Lett
ISSN
0014-5793
Issued Date
2005
Abstract
Chrysin is a natural, biologically active compound extracted
from many plants, honey and propolis. It possesses
potent anti-inflammation, anti-cancer and anti-oxidation properties.
The mechanism by which chrysin suppresses COX-2 expression
remains poorly understood. In the present report, we
investigated the effect of chrysin on the expression of COX-2
in lipopolysaccharide (LPS)-activated Raw 264.7 cells. Chrysin
significantly suppressed the LPS-induced COX-2 protein and
mRNA expression in a dose-dependent manner. The ability of
chrysin to suppress the expression of the COX-2 was investigated
using luciferase reporters controlled by various cis-elements
in COX-2 promoter region. Mutational analysis and
electrophoretic mobility shift assay verified that nuclear factor
for IL-6 was identified as responsible for the chrysin-mediated
COX-2 downregulation. These results will provide new insights
into the anti-inflammatory and anti-carcinogenic properties of
chrysin.
2005 Federation of European Biochemical Societies. Published
by Elsevier B.V. All rights reserved.
Keywords: Chrysin; Cyclooxygenase-2; Nuclear factor for IL-6;
Macrophage; Lipopolysaccharide
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine
Citation
Kyung Jin Woo et al. (2005). Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity. FEBS Lett, 579(3), 705–711. doi: 10.1016/j.febslet.2004.12.048
Type
Article
ISSN
0014-5793
DOI
10.1016/j.febslet.2004.12.048
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34839
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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