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Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

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Author(s)
김상현
Alternative Author(s)
Kim, Sang Hyon
Publication Year
2014
Abstract
Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility
of silicone implants can induce severe side effects, including capsular contracture – an excessive
foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines
the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on
silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl
phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on
the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants
in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments
than bare silicone implants. The observed decrease in a-smooth muscle actin also supported the
alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammationrelated
cells, myeloperoxidase and transforming growth factor-b resulted in reduced inflammation in
the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate
great potential for preventing capsular contracture and developing biocompatible materials for various
biomedical applications.
2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Acta Biomaterialia, Vol.10(10) : 4217-4225, 2014
Type
Article
ISSN
1742-7061
DOI
10.1016/j.actbio.2014.07.007
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34844
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