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Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

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Author(s)
Ji Ung ParkJiyeon HamSukwha KimJi-Hun SeoSang-Hyon KimSeonju LeeHye Jeong MinSunghyun ChoiRa Mi ChoiHeejin KimSohee OhJi An HurTae Hyun ChoiYan Lee
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Acta Biomaterialia
Issued Date
2014
Volume
10
Issue
10
Abstract
Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility
of silicone implants can induce severe side effects, including capsular contracture – an excessive
foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines
the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on
silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl
phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on
the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants
in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments
than bare silicone implants. The observed decrease in a-smooth muscle actin also supported the
alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammationrelated
cells, myeloperoxidase and transforming growth factor-b resulted in reduced inflammation in
the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate
great potential for preventing capsular contracture and developing biocompatible materials for various
biomedical applications.
2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine
Citation
Ji Ung Park et al. (2014). Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings. Acta Biomaterialia, 10(10), 4217–4225. doi: 10.1016/j.actbio.2014.07.007
Type
Article
ISSN
1742-7061
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S1742706114003018?via%3Dihub
DOI
10.1016/j.actbio.2014.07.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34844
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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