Taurine increases glucose sensitivity of UCP2-overexpressing β-cells by ameliorating mitochondrial metabolism

Authors
Jin HanJae Hoon BaeSo-Yeon KimHyun-Young LeeByeong-Churl JangIn-Kyu LeeChi-Heum ChoJeong-Geun LimSeong-Il SuhTaeg-Kyu KwonJong-Wook ParkShin Young RyuWon-Kyung HoYung-E EarmDae-Kyu Song
Department
Dept. of Physiology (생리학); Dept. of Internal Medicine (내과학); Dept. of Obstetrics & Gynecology (산부인과학); Dept. of Molecular Medicine (분자의학); Dept. of Microbiology (미생물학); Dept. of Immunology (면역학); Dept. of Neurology (신경과학)
Issue Date
2004
Citation
American journal of Physiology: Endocrinology and Metabolism, Vol.287(5) : 1008-1018, 2004
ISSN
0193-1849
Abstract
A low-taurine diet during fetal or early postnatal life causes abnormal pancreatic β-cell development. Tissue and plasma taurine concentrations can also be low in diabetic patients. We examined the effect of taurine on impaired glucose responses in diabetic rat β-cells adenovirally overexpressing uncoupling protein (UCP)2, which is upregulated in obesity-related type 2 diabetes. We found that taurine pretreatment restored the ATP-to-ADP (ATP/ADP) ratio and glucose-stimulated insulin secretion in UCP2-infected islets. ATP-sensitive K+ channel sensitivity to dihydroxyacetone, another insulin secretagogue, was similar in both UCP2-infected and control β-cells. In freshly isolated mitochondria from UCP2-overexpressing insulin-secreting (INS)-1 β-cells, methyl pyruvate-mediated mitochondrial Ca2+ increase was significantly ameliorated by taurine. A mitochondrial Ca2+ uniporter blocker, ruthenium red, inhibited the action of taurine. This study suggests that taurine enhances the glucose sensitivity of UCP2-overexpressing β-cells, probably by increasing mitochondrial Ca2+ influx through the Ca2+ uniporter, thereby enhancing mitochondrial metabolic function and increasing the ATP/ADP ratio.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34875
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
Keimyung Author(s)
배재훈; 송대규; 이인규; 조치흠; 장병철; 서성일; 권택규; 박종욱; 임정근
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