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Taurine increases glucose sensitivity of UCP2-overexpressing β-cells by ameliorating mitochondrial metabolism

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Author(s)
Jin HanJae Hoon BaeSo-Yeon KimHyun-Young LeeByeong-Churl JangIn-Kyu LeeChi-Heum ChoJeong-Geun LimSeong-Il SuhTaeg-Kyu KwonJong-Wook ParkShin Young RyuWon-Kyung HoYung-E EarmDae-Kyu Song
Keimyung Author(s)
Bae, Jae HoonSong, Dae KyuLee, In KyuCho, Chi HeumJang, Byeong ChurlSuh, Seong IlKwon, Taeg KyuPark, Jong WookLim, Jeong Geun
Department
Dept. of Physiology (생리학)
Dept. of Internal Medicine (내과학)
Dept. of Obstetrics & Gynecology (산부인과학)
Dept. of Molecular Medicine (분자의학)
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Dept. of Neurology (신경과학)
Journal Title
American journal of Physiology: Endocrinology and Metabolism
Issued Date
2004
Volume
287
Issue
5
Abstract
A low-taurine diet during fetal or early postnatal life causes abnormal pancreatic β-cell development. Tissue and plasma taurine concentrations can also be low in diabetic patients. We examined the effect of taurine on impaired glucose responses in diabetic rat β-cells adenovirally overexpressing uncoupling protein (UCP)2, which is upregulated in obesity-related type 2 diabetes. We found that taurine pretreatment restored the ATP-to-ADP (ATP/ADP) ratio and glucose-stimulated insulin secretion in UCP2-infected islets. ATP-sensitive K+ channel sensitivity to dihydroxyacetone, another insulin secretagogue, was similar in both UCP2-infected and control β-cells. In freshly isolated mitochondria from UCP2-overexpressing insulin-secreting (INS)-1 β-cells, methyl pyruvate-mediated mitochondrial Ca2+ increase was significantly ameliorated by taurine. A mitochondrial Ca2+ uniporter blocker, ruthenium red, inhibited the action of taurine. This study suggests that taurine enhances the glucose sensitivity of UCP2-overexpressing β-cells, probably by increasing mitochondrial Ca2+ influx through the Ca2+ uniporter, thereby enhancing mitochondrial metabolic function and increasing the ATP/ADP ratio.
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