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Neural Evidence for Emotional Involvement in Pathological Alcohol Craving

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Author(s)
구정훈
Alternative Author(s)
Ku, Jeong Hun
Publication Year
2013
Abstract
Aims: Reducing craving is a key to success in the treatment of alcohol dependence. The emotion circuit may be
involved in pathological craving for alcohol. In this study, we investigated neural correlates of emotional involvement in craving in
alcohol dependence. Methods: The study included 17 detoxified alcoholic patients and 25 social drinkers. We used functional magnetic
resonance imaging to examine brain activation (blood oxygen level-dependent signals) while participants reported craving and
emotion in response to visually presented, alcohol-related stimuli and emotional stimuli. Results: In the craving-rating paradigm,
negative emotional stimuli as well as alcohol cues activated craving-related brain regions in alcoholic patients. Activations of the inferior
parietal lobule and dorsolateral prefrontal cortex by negative emotional stimuli were negatively correlated with craving; meanwhile
limbic activation was positively correlated with craving. For the emotion paradigm, greater limbic activation was evident by
alcohol-related stimuli in the alcohol-dependent group. Conclusions: Our findings constitute neural evidence for emotional involvement
in pathological craving for alcohol, underscoring the importance of emotion management in abstinent alcoholic patients for
relapse prevention.
Department
Dept. of Biomedical Engineering (의용공학과)
Publisher
School of Medicine
Citation
Alcohol and Alcoholism, Vol.48(3) : 288-294, 2013
Type
Article
ISSN
0735-0414
DOI
10.1093/alcalc/ags130
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34879
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