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Neural Evidence for Emotional Involvement in Pathological Alcohol Craving

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Author(s)
Eun LeeJeonghun KuYoung-Chul JungHyeongrae LeeSuk Kyoon AnKyung Ran KimKang-Jun YoonKee Namkoong
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Alcohol and Alcoholism
Issued Date
2013
Volume
48
Issue
3
Abstract
Aims: Reducing craving is a key to success in the treatment of alcohol dependence. The emotion circuit may be
involved in pathological craving for alcohol. In this study, we investigated neural correlates of emotional involvement in craving in
alcohol dependence. Methods: The study included 17 detoxified alcoholic patients and 25 social drinkers. We used functional magnetic
resonance imaging to examine brain activation (blood oxygen level-dependent signals) while participants reported craving and
emotion in response to visually presented, alcohol-related stimuli and emotional stimuli. Results: In the craving-rating paradigm,
negative emotional stimuli as well as alcohol cues activated craving-related brain regions in alcoholic patients. Activations of the inferior
parietal lobule and dorsolateral prefrontal cortex by negative emotional stimuli were negatively correlated with craving; meanwhile
limbic activation was positively correlated with craving. For the emotion paradigm, greater limbic activation was evident by
alcohol-related stimuli in the alcohol-dependent group. Conclusions: Our findings constitute neural evidence for emotional involvement
in pathological craving for alcohol, underscoring the importance of emotion management in abstinent alcoholic patients for
relapse prevention.
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Eun Lee et al. (2013). Neural Evidence for Emotional Involvement in Pathological Alcohol Craving. Alcohol and Alcoholism, 48(3), 288–294. doi: 10.1093/alcalc/ags130
Type
Article
ISSN
0735-0414
Source
http://lps3.academic.oup.com.proxy.dsmc.or.kr/alcalc/article/48/3/288/244307
DOI
10.1093/alcalc/ags130
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34879
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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