ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT)

Authors
Jung-Sun KimByeong-Kuk KimIk-Kyung JangDong-Ho ShinYoung-Guk KoDonghoon ChoiMyeong-Ki HongYun-Kyeong ChoChang-Wook NamSeung-Ho HurJin-Ho ChoiYoung Bin SongJoo Yong HahnSeung Hyuk ChoiHyeon Cheol GwonYangsoo Jang
Department
Dept. of Internal Medicine (내과학)
Issue Date
2012
Citation
American Heart Journal, Vol.163(4) : 601-607, 2012
ISSN
0002-8703
Abstract
Background Data on strut surface coverage of second-generation drug-eluting stents (DES) are limited. We investigated stent strut coverage of resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) at 9 months after implantation using optical coherence tomography (OCT). Methods ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT) is a prospective, randomized, multicenter trial comparing ZES-R to EES using OCT at 9 months after stent implantation. The primary end point was the rate of stent strut coverage at 9 months. Results A total of 51 patients were randomized to receive either ZES-R (ZES-R group) or EES (EES group), and 47 stents (24 ZES-R and 23 EES) in 44 of 51 patients were evaluated by OCT both immediately after stent implantation and at 9 months. The neointimal thickness was not significantly different between the 2 groups at 9 months (ZES-R vs EES: 139 ± 58 vs 124 ± 42 μm, P = .31). The mean percentages of uncovered stent struts were 3.3% for ZES-R versus 3.4% for EES at 9 months (P = .51). The proportions of malapposed struts immediately after stent implantation (P = .89) and at 9-month follow-up (P = .34) were 0.8% and 0.7% for ZES-R versus 1.0% and 0.1% for EES, respectively. Thrombi were documented in 1 stent (1 [4.2%] in ZES-R vs 0 [0%] in EES). Conclusion According to the sequential OCT evaluation, ZES-R and EES showed comparable neointimal thickness and the rate of uncovered stent strut at 9 months after stent implantation. (Am Heart J 2012;163:601-7.)
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34882
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
조윤경; 남창욱; 허승호
Full Text
https://linkinghub.elsevier.com/retrieve/pii/S0002870311007769
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