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ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT)

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Author(s)
Jung-Sun KimByeong-Kuk KimIk-Kyung JangDong-Ho ShinYoung-Guk KoDonghoon ChoiMyeong-Ki HongYun-Kyeong ChoChang-Wook NamSeung-Ho HurJin-Ho ChoiYoung Bin SongJoo Yong HahnSeung Hyuk ChoiHyeon Cheol GwonYangsoo Jang
Keimyung Author(s)
Cho, Yun KyeongNam, Chang WookHur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Heart Journal
Issued Date
2012
Volume
163
Issue
4
Abstract
Background Data on strut surface coverage of second-generation drug-eluting stents (DES) are limited. We investigated
stent strut coverage of resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) at 9 months after implantation
using optical coherence tomography (OCT).
Methods ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using
Optical Coherence Tomography (COVER OCT) is a prospective, randomized, multicenter trial comparing ZES-R to EES using
OCT at 9 months after stent implantation. The primary end point was the rate of stent strut coverage at 9 months.
Results A total of 51 patients were randomized to receive either ZES-R (ZES-R group) or EES (EES group), and 47 stents
(24 ZES-R and 23 EES) in 44 of 51 patients were evaluated by OCT both immediately after stent implantation and at 9 months.
The neointimal thickness was not significantly different between the 2 groups at 9 months (ZES-R vs EES: 139 ± 58 vs 124 ± 42
μm, P = .31). The mean percentages of uncovered stent struts were 3.3% for ZES-R versus 3.4% for EES at 9 months (P = .51).
The proportions of malapposed struts immediately after stent implantation (P = .89) and at 9-month follow-up (P = .34) were
0.8% and 0.7% for ZES-R versus 1.0% and 0.1% for EES, respectively. Thrombi were documented in 1 stent (1 [4.2%] in ZES-R
vs 0 [0%] in EES).
Conclusion According to the sequential OCT evaluation, ZES-R and EES showed comparable neointimal thickness and
the rate of uncovered stent strut at 9 months after stent implantation. (Am Heart J 2012;163:601-7.)
Keimyung Author(s)(Kor)
조윤경
남창욱
허승호
Publisher
School of Medicine
Citation
Jung-Sun Kim et al. (2012). ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT). American Heart Journal, 163(4), 601–607. doi: 10.1016/j.ahj.2011.10.016
Type
Article
ISSN
0002-8703
Source
https://linkinghub.elsevier.com/retrieve/pii/S0002870311007769
DOI
10.1016/j.ahj.2011.10.016
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34882
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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