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Comparison of Early Strut Coverage Between Zotarolimus- and Everolimus-Eluting Stents Using Optical Coherence Tomography

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Author(s)
조윤경남창욱허승호
Alternative Author(s)
Cho, Yun KyeongNam, Chang WookHur, Seung Ho
Publication Year
2013
Abstract
There have been no optical coherence tomographic (OCT) data directly comparing the
pattern of strut coverage between the 2 second-generation drug-eluting stents in the early
period. The aim of this prospective study was to evaluate early strut coverage using optical
coherence tomography 3 months after Resolute zotarolimus-eluting stent (ZES-R) or
everolimus-eluting stent (EES) implantation in de novo coronary artery lesions. A total of
40 patients who were suitable for the OCT procedure and consented to the study protocol
were randomized 1:1 to receive either ZES-R or EES. Among these patients, 35 stented
lesions (18 ZES-R, 17 EES) in 34 patients were evaluated by optical coherence tomography
immediately and 3 months after stent implantation. Neointimal hyperplasia thickness,
percentage of uncovered struts, and the proportion of malapposed struts were measured at
1-mm intervals. An uncovered strut was defined as having a neointimal hyperplasia
thickness of 0 mm. At the 3-month OCT evaluation, mean neointimal hyperplasia thickness
(ZES-R vs EES 74 – 41 vs 75 – 35 mm, p [ 0.89) and mean percentage of uncovered struts
(ZES-R vs EES 6.2 – 6.9 vs 4.7 – 5.1%, p [ 0.62) were not significantly different between
the groups. The percentage of malapposed struts was also similar between the groups
(0.7 – 2.2% for ZES-R and 0.7 – 1.7% for EES, p [ 0.64). Thrombi were documented in
3 stents (1 [5.6%] in a ZES-R vs 2 [11.8%] in EES, p[0.60). In conclusion, early stent strut
coverage on the basis of serial OCT evaluation was comparable between ZES-R and EES
3 months after stent implantation. 2012 Elsevier Inc. All rights reserved. (Am J Cardiol
2012;-:-e-)
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
American Journal of Cardiology, Vol.111(1) : 1-5, 2013
Type
Article
ISSN
0002-9149
DOI
10.1016/j.amjcard.2012.08.037
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34887
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