Comparison of Early Strut Coverage Between Zotarolimus- and Everolimus-Eluting Stents Using Optical Coherence Tomography

Seunghwan KimJung-Sun KimDong-Ho ShinByeong-Keuk KimYoung-Guk KoDonghoon ChoiYun-Kyeong ChoChang-Wook NamSeung-Ho HurYangsoo JangMyeong-Ki Hong
Dept. of Internal Medicine (내과학)
Issue Date
American Journal of Cardiology, Vol.111(1) : 1-5, 2013
There have been no optical coherence tomographic (OCT) data directly comparing the pattern of strut coverage between the 2 second-generation drug-eluting stents in the early period. The aim of this prospective study was to evaluate early strut coverage using optical coherence tomography 3 months after Resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) implantation in de novo coronary artery lesions. A total of 40 patients who were suitable for the OCT procedure and consented to the study protocol were randomized 1:1 to receive either ZES-R or EES. Among these patients, 35 stented lesions (18 ZES-R, 17 EES) in 34 patients were evaluated by optical coherence tomography immediately and 3 months after stent implantation. Neointimal hyperplasia thickness, percentage of uncovered struts, and the proportion of malapposed struts were measured at 1-mm intervals. An uncovered strut was defined as having a neointimal hyperplasia thickness of 0 mm. At the 3-month OCT evaluation, mean neointimal hyperplasia thickness (ZES-R vs EES 74 – 41 vs 75 – 35 mm, p [ 0.89) and mean percentage of uncovered struts (ZES-R vs EES 6.2 – 6.9 vs 4.7 – 5.1%, p [ 0.62) were not significantly different between the groups. The percentage of malapposed struts was also similar between the groups (0.7 – 2.2% for ZES-R and 0.7 – 1.7% for EES, p [ 0.64). Thrombi were documented in 3 stents (1 [5.6%] in a ZES-R vs 2 [11.8%] in EES, p[0.60). In conclusion, early stent strut coverage on the basis of serial OCT evaluation was comparable between ZES-R and EES 3 months after stent implantation. 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;-:-e-)
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조윤경; 남창욱; 허승호
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