A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia

Jay Cheol KwonEung Gyu KimJae Woo KimOh Dae KwonBong Goo YooHyon Ah YiNack Cheon ChoiSeon Young AhnByung Hwa Lee, Myong Jin KangDae Seob Choi
Dept. of Neurology (신경과학)
Issue Date
American Journal of Alzheimer's Disease & Other Dementias, Vol.24(4) : 293-301, 2009
Objectives: To evaluate the efficacy and tolerability of donepezil in patients with Binswanger type subcortical vascular dementia. Methods: Patients (n ¼ 34, mean age ¼ 71.8 + 7.12) with Binswanger type subcortical vascular dementia from 8 multicenter, according to clinical and neuroradiological working criteria, were selected to receive donepezil 5 mg/day (n ¼ 2) or donepezil 10 mg/day (n ¼ 32, after 5 mg/day) for 24 weeks. Our primary endpoints were change from baseline to weeks 12 and 24 in the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D) and the Korean version of neuropsychiatric inventory (K-NPI). Results: A total of 24 patients received donepezil completed the study (mean age ¼ 72.0 + 7.5 K-Mini-Mental State Examination [MMSE] ¼ 21.0 + 5.1). After 12 weeks and 24 weeks, patients showed improvements in cognitive function on the SNSB-D compared baseline of 16.29 points at 12 weeks (P < .05) and 12.44 points at 24 weeks (P < .05). Significant improvements were shown in only memory domain, immediate verbal recall and delayed recall tests. Subgroup with better cognitive function (SNSB-D > 100) were more effective in frontal and memory domains than the other subgroup (SNSB-D < 100). Withdrawal rates due to adverse events were very low (4.16%). Conclusions: Donepezil-treated patients with Binswanger type subcortical vascular dementia demonstrated significant improvement in cognition compared with baseline, and donepezil was well tolerated. Keywords: Binswanger type subcortical vascular dementia; donepezil; cognition
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