A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia
- Alternative Author(s)
- Yi, Hyon Ah
- Publication Year
- Objectives: To evaluate the efficacy and tolerability of
donepezil in patients with Binswanger type subcortical
vascular dementia. Methods: Patients (n ¼ 34, mean
age ¼ 71.8 + 7.12) with Binswanger type subcortical
vascular dementia from 8 multicenter, according to
clinical and neuroradiological working criteria, were
selected to receive donepezil 5 mg/day (n ¼ 2) or donepezil
10 mg/day (n ¼ 32, after 5 mg/day) for 24 weeks.
Our primary endpoints were change from baseline to
weeks 12 and 24 in the Seoul Neuropsychological
Screening Battery-Dementia version (SNSB-D) and the
Korean version of neuropsychiatric inventory (K-NPI).
Results: A total of 24 patients received donepezil
completed the study (mean age ¼ 72.0 + 7.5
K-Mini-Mental State Examination [MMSE] ¼ 21.0
+ 5.1). After 12 weeks and 24 weeks, patients showed
improvements in cognitive function on the SNSB-D
compared baseline of 16.29 points at 12 weeks (P <
.05) and 12.44 points at 24 weeks (P < .05). Significant
improvements were shown in only memory domain,
immediate verbal recall and delayed recall tests. Subgroup
with better cognitive function (SNSB-D > 100)
were more effective in frontal and memory domains
than the other subgroup (SNSB-D < 100). Withdrawal
rates due to adverse events were very low (4.16%).
Conclusions: Donepezil-treated patients with Binswanger
type subcortical vascular dementia demonstrated
significant improvement in cognition compared with
baseline, and donepezil was well tolerated.
Keywords: Binswanger type subcortical vascular
dementia; donepezil; cognition
- School of Medicine
- Jay Cheol Kwon. (2009). A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia. American Journal of Alzheimer's Disease & Other Dementias, 24(4), 293-301. doi: 10.1177/1533317509334960
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