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A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia

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Author(s)
Jay Cheol KwonEung Gyu KimJae Woo KimOh Dae KwonBong Goo YooHyon Ah YiNack Cheon ChoiSeon Young AhnByung Hwa LeeMyong Jin KangDae Seob Choi
Keimyung Author(s)
Yi, Hyon Ah
Journal Title
American Journal of Alzheimer's Disease & Other Dementias
Issued Date
2009
Volume
24
Issue
4
Abstract
Objectives: To evaluate the efficacy and tolerability of
donepezil in patients with Binswanger type subcortical
vascular dementia. Methods: Patients (n ¼ 34, mean
age ¼ 71.8 + 7.12) with Binswanger type subcortical
vascular dementia from 8 multicenter, according to
clinical and neuroradiological working criteria, were
selected to receive donepezil 5 mg/day (n ¼ 2) or donepezil
10 mg/day (n ¼ 32, after 5 mg/day) for 24 weeks.
Our primary endpoints were change from baseline to
weeks 12 and 24 in the Seoul Neuropsychological
Screening Battery-Dementia version (SNSB-D) and the
Korean version of neuropsychiatric inventory (K-NPI).
Results: A total of 24 patients received donepezil
completed the study (mean age ¼ 72.0 + 7.5
K-Mini-Mental State Examination [MMSE] ¼ 21.0
+ 5.1). After 12 weeks and 24 weeks, patients showed
improvements in cognitive function on the SNSB-D
compared baseline of 16.29 points at 12 weeks (P <
.05) and 12.44 points at 24 weeks (P < .05). Significant
improvements were shown in only memory domain,
immediate verbal recall and delayed recall tests. Subgroup
with better cognitive function (SNSB-D > 100)
were more effective in frontal and memory domains
than the other subgroup (SNSB-D < 100). Withdrawal
rates due to adverse events were very low (4.16%).
Conclusions: Donepezil-treated patients with Binswanger
type subcortical vascular dementia demonstrated
significant improvement in cognition compared with
baseline, and donepezil was well tolerated.
Keywords: Binswanger type subcortical vascular
dementia; donepezil; cognition
Keimyung Author(s)(Kor)
이현아
Publisher
School of Medicine
Citation
Jay Cheol Kwon et al. (2009). A Multicenter, Open-Label, 24-Week Follow-Up Study for Efficacy on Cognitive Function of Donepezil in Binswanger-Type Subcortical Vascular Dementia. American Journal of Alzheimer’s Disease & Other Dementias, 24(4), 293–301. doi: 10.1177/1533317509334960
Type
Article
ISSN
1533-3175
Source
http://journals.sagepub.com/doi/abs/10.1177/1533317509334960?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
DOI
10.1177/1533317509334960
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34918
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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