Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas
- Affiliated Author(s)
- 도영록; 권기영; 송홍석
- Alternative Author(s)
- Do, Young Rok; Kwon, Ki Young; Song, Hong Suk
- Journal Title
- Annals of Hematology
- ISSN
- 0939-5555
- Issued Date
- 2006
- Abstract
- Apoptosis pathways are known to be involved in
the pathogenesis of peripheral T-cell lymphomas (PTCLs).
As such, the current study attempted to investigate the
overexpression of Bcl-2, Bax, or p53 with respect to the
progression of PTCL. Paraffin-embedded specimens from
74 patients were analyzed immunohistochemically for
Bcl-2, Bax, or p53 overexpression including PTCLunspecified
(n=45), extranodal natural killer cell/T-cell
lymphoma (n=10), angioimmunoblastic T-cell lymphoma
(n=7), anaplastic large cell lymphoma (n=7), and cutaneous
T-cell lymphoma (n=5). The Bcl-2 overexpression was
exhibited in 33 (45%), Bax, 17 (23%), and p53, 33 patients
(45%). Bcl-2 overexpression was strongly associated with
advanced stage (p=0.021) and higher international prognostic
indices (IPI) (p=0.038). Bcl-2+/p53+ group was
found to be associated with advanced stage (p=0.008) and
higher IPI (p=0.001), compared with the other groups. The
independent expression of Bcl-2 or p53 was not correlated
with survival. Meanwhile, when confined to Bcl-2 overexpressing
groups, p53 overexpression was significantly
associated with poor survival (p=0.05), as the 3-year OS
rate was 82.5% for Bcl-2+/p53- cases, yet only 32.9% for
Bcl-2+/p53+ cases. Multivariate analyses for OS found the
Bcl-2/p53 co-expression (p=0.004) as independent prognostic
factor, together with advanced stage (p<0.001) and
higher prognostic index for PTCL (p=0.008). Bcl-2
overexpression seemed to correlate with the progression
of PTCL interacting with a p53-dependent pathway.
Keywords Bcl-2 . p53 . Peripheral T-cell lymphomas .
Apoptosis-related gene
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.