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Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas

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Author(s)
Jin Tae JungDong Hwan KimEun Kyung KwakJong Gwang KimTae In ParkSang Kyun SohnYoung Rok DoKi Young KwonHong Suk SongEui Hyun ParkKyu Bo Lee
Keimyung Author(s)
Do, Young RokKwon, Ki YoungSong, Hong Suk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Annals of Hematology
Issued Date
2006
Volume
85
Issue
9
Abstract
Apoptosis pathways are known to be involved in
the pathogenesis of peripheral T-cell lymphomas (PTCLs).
As such, the current study attempted to investigate the
overexpression of Bcl-2, Bax, or p53 with respect to the
progression of PTCL. Paraffin-embedded specimens from
74 patients were analyzed immunohistochemically for
Bcl-2, Bax, or p53 overexpression including PTCLunspecified
(n=45), extranodal natural killer cell/T-cell
lymphoma (n=10), angioimmunoblastic T-cell lymphoma
(n=7), anaplastic large cell lymphoma (n=7), and cutaneous
T-cell lymphoma (n=5). The Bcl-2 overexpression was
exhibited in 33 (45%), Bax, 17 (23%), and p53, 33 patients
(45%). Bcl-2 overexpression was strongly associated with
advanced stage (p=0.021) and higher international prognostic
indices (IPI) (p=0.038). Bcl-2+/p53+ group was
found to be associated with advanced stage (p=0.008) and
higher IPI (p=0.001), compared with the other groups. The
independent expression of Bcl-2 or p53 was not correlated
with survival. Meanwhile, when confined to Bcl-2 overexpressing
groups, p53 overexpression was significantly
associated with poor survival (p=0.05), as the 3-year OS
rate was 82.5% for Bcl-2+/p53- cases, yet only 32.9% for
Bcl-2+/p53+ cases. Multivariate analyses for OS found the
Bcl-2/p53 co-expression (p=0.004) as independent prognostic
factor, together with advanced stage (p<0.001) and
higher prognostic index for PTCL (p=0.008). Bcl-2
overexpression seemed to correlate with the progression
of PTCL interacting with a p53-dependent pathway.
Keywords Bcl-2 . p53 . Peripheral T-cell lymphomas .
Apoptosis-related gene
Keimyung Author(s)(Kor)
도영록
권기영
송홍석
Publisher
School of Medicine
Citation
Jin Tae Jung et al. (2006). Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas. Annals of Hematology, 85(9), 575–581. doi: 10.1007/s00277-006-0127-z
Type
Article
ISSN
0939-5555
Source
https://link.springer.com/article/10.1007/s00277-006-0127-z
DOI
10.1007/s00277-006-0127-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34968
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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