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Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing

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Author(s)
김상현장혁원최미선권선영
Alternative Author(s)
Kim, Sang HyonChang, Hyuk WonChoe, Mi SunKwon, Sun Young
Publication Year
2013
Abstract
Anthocyanins are known to have antioxidant and antiinflammatory
effects.We hypothesized that anthocyanins would enhance wound healing
in Sprague-Dawley rats. The purpose of this study was to evaluate our hypothesis
and investigate the mechanism of wound healing enhancement. The cytoprotective
effect of an immortalized epidermal keratinocyte cell line (HaCaT)
and human neonatal dermal fibroblasts in response to various concentrations
of anthocyanins was determined. Vascular endothelial growth factor (VEGF)
and thrombospondin 1 (TSP1) of HaCaT were measured by Western blot
analysis. Anthocyanins were applied to thewounds in rats, and the healing ratio
was calculated. Tissue VEGF, TSP1, CD31, nuclear factor-JB, and phosphorylation
of IJB> were measured. The viability of the HaCaT cell line
and human neonatal dermal fibroblasts increased under cytotoxicity by H2O2
in the anthocyanin-treated groups. The VEGF in the anthocyanin-treated groups
increased, whereas TSP1 decreased. Wounds in the experimental groups
healed faster, and VEGF and CD31 increased in the experimental groups,
whereas TSP1 decreased. Anthocyanins inhibited the translocation of nuclear
factor-JB (p65) from cytosol to nucleus and also prevented the phosphorylation
of IJB>. Anthocyanins enhance wound healing through a cytoprotective
effect, enhancement of angiogenesis, and an antiinflammatory effect.
Key Words: anthocyanins, wound healing, VEGF, TSP1, NF-JB, IJB>
(Ann Plast Surg 2013;71: 415Y420)
Department
Dept. of Internal Medicine (내과학)
Dept. of Radiology (영상의학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Annals of Plastic Surgery, Vol.71(4) : 415-420, 2013
Type
Article
ISSN
0148-7043
DOI
10.1097/SAP.0b013e31824ca62b
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34981
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