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Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing

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Author(s)
Lianji XuTae Hyun ChoiSukwha KimSang-Hyon KimHyuk Won ChangMisun ChoeSun Young KwonJi An HurSung Chul ShinJong Il ChungDawon KangDuo Zhang
Keimyung Author(s)
Kim, Sang HyonChang, Hyuk WonChoe, Mi SunKwon, Sun Young
Department
Dept. of Internal Medicine (내과학)
Dept. of Radiology (영상의학)
Dept. of Pathology (병리학)
Journal Title
Annals of Plastic Surgery
Issued Date
2013
Volume
71
Issue
4
Abstract
Anthocyanins are known to have antioxidant and antiinflammatory
effects.We hypothesized that anthocyanins would enhance wound healing
in Sprague-Dawley rats. The purpose of this study was to evaluate our hypothesis
and investigate the mechanism of wound healing enhancement. The cytoprotective
effect of an immortalized epidermal keratinocyte cell line (HaCaT)
and human neonatal dermal fibroblasts in response to various concentrations
of anthocyanins was determined. Vascular endothelial growth factor (VEGF)
and thrombospondin 1 (TSP1) of HaCaT were measured by Western blot
analysis. Anthocyanins were applied to thewounds in rats, and the healing ratio
was calculated. Tissue VEGF, TSP1, CD31, nuclear factor-JB, and phosphorylation
of IJB> were measured. The viability of the HaCaT cell line
and human neonatal dermal fibroblasts increased under cytotoxicity by H2O2
in the anthocyanin-treated groups. The VEGF in the anthocyanin-treated groups
increased, whereas TSP1 decreased. Wounds in the experimental groups
healed faster, and VEGF and CD31 increased in the experimental groups,
whereas TSP1 decreased. Anthocyanins inhibited the translocation of nuclear
factor-JB (p65) from cytosol to nucleus and also prevented the phosphorylation
of IJB>. Anthocyanins enhance wound healing through a cytoprotective
effect, enhancement of angiogenesis, and an antiinflammatory effect.
Key Words: anthocyanins, wound healing, VEGF, TSP1, NF-JB, IJB>
(Ann Plast Surg 2013;71: 415Y420)
Keimyung Author(s)(Kor)
김상현
장혁원
최미선
권선영
Publisher
School of Medicine
Citation
Lianji Xu et al. (2013). Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing. Annals of Plastic Surgery, 71(4), 415–420. doi: 10.1097/SAP.0b013e31824ca62b
Type
Article
ISSN
0148-7043
Source
http://insights.ovid.com/pubmed?pmid=23407247
DOI
10.1097/SAP.0b013e31824ca62b
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34981
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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