Expression of Basement Membrane Gene in Cultured Skin Fibroblasts from Patients with Diabetes Mellitus

Authors
Byung Chun KimKyu Suk Lee
Department
Dept. of Dermatology (피부과학)
Issue Date
1996
Citation
Annals of Dermatology, Vol.8(1) : 1-5, 1996
ISSN
1013-9090
Abstract
Background: Bullous eruption of diabetes(BD) is a rare cutaneous sign of diabetes melli- tus(DM). The mechwism for the development of these lesions is unknown, although speculation has ranged from trauma to vascular insufficiency. Objectwe: Our purpose is to evaluate the diRerence of basement membrane gene expression in cultured skin fibroblasts between patients with diabetes and normal controls. Methods: TataI RKA was extracted kom cultured skin fibroblasts of DM and normal, and then Northern blot and slot-blot hybridixations were done. Resaalts: The mRNA levels of a(I) procoUagen, c(IV) procollagen, 6bronectin, and laminin Bl were not altered significantly in the DM. Conclusion: Our results suggest that BB has na relevance to the alteration of basement membrane components. Further studies are needed to clarify the underlying pathogenic mechanism of BD. (Ann Dermatol 8:(1) 1-5, 1996).
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/34996
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
Keimyung Author(s)
김병천; 이규석
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