Association of the Methylenetetrahydrofolate Reductase Polymorphism in Korean Patients with Childhood Acute Lymphoblastic Leukemia

Authors
NAM KEUN KIMSO YOUNG CHONGMOON JU JANGSEUNG HO HONGHEUNG SIK KIMEUN KYUNG CHOJUNG AE LEEMYUNG JU AHNCHUL SOO KIMDOYEUN OH
Department
Dept. of Internal Medicine (내과학)
Issue Date
2006
Citation
Anticancer Research, Vol.26(4B) : 2879-2881, 2006
ISSN
0250-7005
Abstract
Background: Methylenetetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer. Therefore, it was hypothesized that the MTHFR polymorphisms are associated with the risk of childhood ALL in the Korean population. Patients and Methods: DNA samples taken from 66 patients with ALL and 100 age-matched controls were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for detection of MTHFR C677T and A1298C mutations. Results: The frequency of the AC genotype for MTHFR A1298C polymorphism was significantly different between the controls and the cases (OR, 2.22; CI, 95% 1.09-4.51, p=0.03). The 1298AC+CC genotype was also significantly different (OR, 2.11; 95% CI, 1.06-4.22; p=0.049). There was, however, no significant difference for MTHFR C677T polymorphism and combined genotype frequencies between the two groups. Conclusion: Although no consistent results on associations between MTHFR A1298C polymorphism and ALL in the populations studied were obtained, the A1298C polymorphism, at least in Koreans, may be a genetic determinant among childhood ALL patients.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35060
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
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