계명대학교 의학도서관 Repository

Association of the Methylenetetrahydrofolate Reductase Polymorphism in Korean Patients with Childhood Acute Lymphoblastic Leukemia

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Author(s)
NAM KEUN KIMSO YOUNG CHONGMOON JU JANGSEUNG HO HONGHEUNG SIK KIMEUN KYUNG CHOJUNG AE LEEMYUNG JU AHNCHUL SOO KIMDOYEUN OH
Keimyung Author(s)
Kim, Heung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Anticancer Research
Issued Date
2006
Volume
26
Issue
4B
Abstract
Background: Methylenetetrahydrofolate reductase plays a central role in converting folate to methyl donor for DNA methylation. Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer. Therefore, it was hypothesized that the MTHFR polymorphisms are associated with the risk of childhood ALL in the Korean population. Patients and Methods: DNA samples taken from 66 patients with ALL and 100 age-matched controls were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for detection of MTHFR C677T and A1298C mutations. Results: The frequency of the AC genotype for MTHFR A1298C polymorphism was significantly different between the controls and the cases (OR, 2.22; CI, 95% 1.09-4.51, p=0.03). The 1298AC+CC genotype was also significantly different (OR, 2.11; 95% CI, 1.06-4.22; p=0.049). There was, however, no significant difference for MTHFR C677T polymorphism and combined genotype frequencies between the two groups. Conclusion: Although no consistent results on associations between MTHFR A1298C polymorphism and ALL in the populations studied were obtained, the A1298C polymorphism, at least in Koreans, may be a genetic determinant among childhood ALL patients.
Keimyung Author(s)(Kor)
김흥식
Publisher
School of Medicine
Citation
NAM KEUN KIM et al. (2006). Association of the Methylenetetrahydrofolate Reductase Polymorphism in Korean Patients with Childhood Acute Lymphoblastic Leukemia. Anticancer Research, 26(4B), 2879–2881.
Type
Article
ISSN
0250-7005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35060
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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