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Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)

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Author(s)
구정훈
Alternative Author(s)
Ku, Jeong Hun
Publication Year
2015
Abstract
Background/Objectives: Although hypertension is known to be a risk factor for AD, the effects of
hypertension on brain function in AD patients are not well understood. We investigated alterations in
resting-state functional connectivity according to the presence of hypertension in AD patients by using a
method of correlation analysis based on a seed region in the posterior cingulate cortex (PCC). We also
determined whether differences in resting-state connectivity were associated with gray matter atrophy.
Methods: Thirty-seven AD patients (18 patients with hypertension and 19 patients without
hypertension) underwent the resting-state functional magnetic resonance imaging. We obtained the
PCC maps by a temporal correlation method, to identify alterations in the functional connectivity of the
PCC in hypertensive group relative to non-hypertensive group. Voxel-based morphometry analysis was
also applied to adjust the confounding effect of gray matter atrophy.
Results: We detected a decreased connectivity to the PCC in the regions of subgenual anterior cingulated
cortex (ACC) in hypertensive group relative to non-hypertensive group. However, we observed a pattern
of increased connectivity between the PCC and the left inferior parietal cortex in hypertensive group.
After correction for gray matter atrophy, all detected regions still remained significant.
Conclusions: Altered connectivity in AD patients with hypertension suggests the possibility that
hypertension impairs resting-state functional connectivity of the AD brain, inducing a compensational
process outside the impaired networks or disequilibrium in brain connectivity. This finding may account
for an additional contribution of hypertension to the pathophysiology of AD.
Department
Dept. of Biomedical Engineering (의용공학과)
Publisher
School of Medicine
Citation
Archives of Gerontology and Geriatrics, Vol.60(1) : 210-216, 2015
Type
Article
ISSN
0167-4943
DOI
10.1016/j.archger.2014.09.012
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35086
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