계명대학교 의학도서관 Repository

Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)

Metadata Downloads
Author(s)
Sang Joon SonJinna KimEun LeeJin Young ParkKee NamkoongChang Hyung HongJeonghun KuEosu KimByoung Hoon Oh
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Archives of Gerontology and Geriatrics
Issued Date
2015
Volume
60
Issue
1
Abstract
Background/Objectives: Although hypertension is known to be a risk factor for AD, the effects of
hypertension on brain function in AD patients are not well understood. We investigated alterations in
resting-state functional connectivity according to the presence of hypertension in AD patients by using a
method of correlation analysis based on a seed region in the posterior cingulate cortex (PCC). We also
determined whether differences in resting-state connectivity were associated with gray matter atrophy.
Methods: Thirty-seven AD patients (18 patients with hypertension and 19 patients without
hypertension) underwent the resting-state functional magnetic resonance imaging. We obtained the
PCC maps by a temporal correlation method, to identify alterations in the functional connectivity of the
PCC in hypertensive group relative to non-hypertensive group. Voxel-based morphometry analysis was
also applied to adjust the confounding effect of gray matter atrophy.
Results: We detected a decreased connectivity to the PCC in the regions of subgenual anterior cingulated
cortex (ACC) in hypertensive group relative to non-hypertensive group. However, we observed a pattern
of increased connectivity between the PCC and the left inferior parietal cortex in hypertensive group.
After correction for gray matter atrophy, all detected regions still remained significant.
Conclusions: Altered connectivity in AD patients with hypertension suggests the possibility that
hypertension impairs resting-state functional connectivity of the AD brain, inducing a compensational
process outside the impaired networks or disequilibrium in brain connectivity. This finding may account
for an additional contribution of hypertension to the pathophysiology of AD.
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Sang Joon Son et al. (2015). Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer’s disease (AD). Archives of Gerontology and Geriatrics, 60(1), 210–216. doi: 10.1016/j.archger.2014.09.012
Type
Article
ISSN
0167-4943
Source
https://www.sciencedirect.com/science/article/pii/S0167494314001794?via%3Dihub
DOI
10.1016/j.archger.2014.09.012
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35086
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.