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Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors

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Author(s)
강유나류승완송홍석
Alternative Author(s)
Kang, Yu NaRyu, Seung WanSong, Hong Suk
Publication Year
2014
Abstract
Aim: The vascular endothelial growth factor (VEGF) or its family might play role in tumor-related
angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the
present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the
prognosis for GIST patients.
Methods: In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present
study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four VEGF (-2578C/A,
-1498C/T, -634G/C, and +936C/T) and one VEGFR-2 (+1416A/T) gene polymorphisms were determined
using a Sequenom MassARRAY system.
Results: With a median follow up of 18.4 months, the estimated 5-year relapse-free survival and overall
survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of
disease, pathology and risk stratification, no significant association was observed between the polymorphism
of the VEGF and VEGFR-2 genes and survival.
Conclusion: None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was
found to be an independent prognostic marker for Korean patients with surgically resected GIST. However,
further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms
as a prognostic biomarker for GIST patients.
Key words: gastrointestinal stromal tumor, prognosis, single nucleotide polymorphism, vascular endothelial
growth factor, vascular endothelial growth factor receptor.
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Asia-Pacific Journal of Clinical Oncology, Vol.10(2) : e40-e45, 2014
Type
Article
ISSN
1743-7555
DOI
10.1111/ajco.12068
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35109
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