Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors

Authors
Byung Woog KANGJong Gwang KIMYee Soo CHAEHan Ik BAE Ohkyoung KWONHo Young CHUNGWansik YUHong Suk SONGYu Na KANGSeung Wan RYUKyung Hee LEEYoung Kyung BAEJoon Hyuk CHOISe Won KIMHun-Mo RYOOChang-Ho CHOHyun-Dong CHAEKyun Woo PARKMi Jin GUByung-Jo BAE
Department
Dept. of Pathology (병리학); Dept. of Surgery (외과학); Dept. of Internal Medicine (내과학)
Issue Date
2014
Citation
Asia-Pacific Journal of Clinical Oncology, Vol.10(2) : e40-e45, 2014
ISSN
1743-7555
Abstract
Aim: The vascular endothelial growth factor (VEGF) or its family might play role in tumor-related angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the prognosis for GIST patients. Methods: In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four VEGF (-2578C/A, -1498C/T, -634G/C, and +936C/T) and one VEGFR-2 (+1416A/T) gene polymorphisms were determined using a Sequenom MassARRAY system. Results: With a median follow up of 18.4 months, the estimated 5-year relapse-free survival and overall survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of disease, pathology and risk stratification, no significant association was observed between the polymorphism of the VEGF and VEGFR-2 genes and survival. Conclusion: None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST. However, further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms as a prognostic biomarker for GIST patients. Key words: gastrointestinal stromal tumor, prognosis, single nucleotide polymorphism, vascular endothelial growth factor, vascular endothelial growth factor receptor.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/35109
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
Keimyung Author(s)
강유나; 류승완; 송홍석
Full Text
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/ajco.12068
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