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Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors

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Author(s)
강유나류승완송홍석
Alternative Author(s)
Kang, Yu NaRyu, Seung WanSong, Hong Suk
Publication Year
2014
Abstract
Aim: The vascular endothelial growth factor (VEGF) or its family might play role in tumor-related
angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the
present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the
prognosis for GIST patients.
Methods: In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present
study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four VEGF (-2578C/A,
-1498C/T, -634G/C, and +936C/T) and one VEGFR-2 (+1416A/T) gene polymorphisms were determined
using a Sequenom MassARRAY system.
Results: With a median follow up of 18.4 months, the estimated 5-year relapse-free survival and overall
survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of
disease, pathology and risk stratification, no significant association was observed between the polymorphism
of the VEGF and VEGFR-2 genes and survival.
Conclusion: None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was
found to be an independent prognostic marker for Korean patients with surgically resected GIST. However,
further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms
as a prognostic biomarker for GIST patients.
Key words: gastrointestinal stromal tumor, prognosis, single nucleotide polymorphism, vascular endothelial
growth factor, vascular endothelial growth factor receptor.
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