Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors
- Byung Woog KANG; Jong Gwang KIM; Yee Soo CHAE; Han Ik BAE
Ohkyoung KWON; Ho Young CHUNG; Wansik YU; Hong Suk SONG; Yu Na KANG; Seung Wan RYU; Kyung Hee LEE; Young Kyung BAE; Joon Hyuk CHOI; Se Won KIM; Hun-Mo RYOO; Chang-Ho CHO; Hyun-Dong CHAE; Kyun Woo PARK; Mi Jin GU; Byung-Jo BAE
- Dept. of Pathology (병리학); Dept. of Surgery (외과학); Dept. of Internal Medicine (내과학)
- Issue Date
- Asia-Pacific Journal of Clinical Oncology, Vol.10(2) : e40-e45, 2014
- Aim: The vascular endothelial growth factor (VEGF) or its family might play role in tumor-related
angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the
present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the
prognosis for GIST patients.
Methods: In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present
study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four VEGF (-2578C/A,
-1498C/T, -634G/C, and +936C/T) and one VEGFR-2 (+1416A/T) gene polymorphisms were determined
using a Sequenom MassARRAY system.
Results: With a median follow up of 18.4 months, the estimated 5-year relapse-free survival and overall
survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of
disease, pathology and risk stratification, no significant association was observed between the polymorphism
of the VEGF and VEGFR-2 genes and survival.
Conclusion: None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was
found to be an independent prognostic marker for Korean patients with surgically resected GIST. However,
further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms
as a prognostic biomarker for GIST patients.
Key words: gastrointestinal stromal tumor, prognosis, single nucleotide polymorphism, vascular endothelial
growth factor, vascular endothelial growth factor receptor.
- Appears in Collections:
- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
- Keimyung Author(s)
- 강유나; 류승완; 송홍석
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