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Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors

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Author(s)
Byung Woog KANGJong Gwang KIMYee Soo CHAEHan Ik BAE Ohkyoung KWONHo Young CHUNGWansik YUHong Suk SONGYu Na KANGSeung Wan RYUKyung Hee LEEYoung Kyung BAEJoon Hyuk CHOISe Won KIMHun-Mo RYOOChang-Ho CHOHyun-Dong CHAEKyun Woo PARKMi Jin GUByung-Jo BAE
Keimyung Author(s)
Kang, Yu NaRyu, Seung WanSong, Hong Suk
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Journal Title
Asia-Pacific Journal of Clinical Oncology
Issued Date
2014
Volume
10
Issue
2
Abstract
Aim: The vascular endothelial growth factor (VEGF) or its family might play role in tumor-related
angiogenesis in gastrointestinal stromal tumors (GIST), thereby affecting the prognosis. Accordingly, the
present study analyzed the impact of VEGF and VEGF receptor-2 (VEGFR-2) gene polymorphisms on the
prognosis for GIST patients.
Methods: In all, 213 consecutive patients with GIST from five medical centers were enrolled in the present
study. The genomic DNA was extracted from paraffin-embedded tumor tissue, and four VEGF (-2578C/A,
-1498C/T, -634G/C, and +936C/T) and one VEGFR-2 (+1416A/T) gene polymorphisms were determined
using a Sequenom MassARRAY system.
Results: With a median follow up of 18.4 months, the estimated 5-year relapse-free survival and overall
survival rates were 70 and 87%, respectively. In a multivariate analysis including age, sex, primary site of
disease, pathology and risk stratification, no significant association was observed between the polymorphism
of the VEGF and VEGFR-2 genes and survival.
Conclusion: None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was
found to be an independent prognostic marker for Korean patients with surgically resected GIST. However,
further studies on a larger scale are warranted to clarify the role of VEGF and VEGFR gene polymorphisms
as a prognostic biomarker for GIST patients.
Key words: gastrointestinal stromal tumor, prognosis, single nucleotide polymorphism, vascular endothelial
growth factor, vascular endothelial growth factor receptor.
Keimyung Author(s)(Kor)
강유나
류승완
송홍석
Publisher
School of Medicine
Citation
Byung Woog KANG et al. (2014). Clinical significance of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 gene polymorphisms in patients with gastrointestinal stromal tumors. Asia-Pacific Journal of Clinical Oncology, 10(2), e40–e45. doi: 10.1111/ajco.12068
Type
Article
ISSN
1743-7555
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1111/ajco.12068
DOI
10.1111/ajco.12068
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35109
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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